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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 β-lactamases in Klebsiella pneumoniae
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Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 β-lactamases in Klebsiella pneumoniae

Ying-Tsong Chen, Tsai-Ling Lauderdale, Tsai-Lien Liao, Yih-Ru Shiau, Hung-Yu Shu, Ken-Ming Wu, Jing-Jou Yan, Ih-Jen SuShih-Feng Tsai
Antimicrobial Agents and Chemotherapy, 卷.51(8), 頁碼.3004-3007
08/2007
PMID: 17526756

摘要

Pharmacology (medical)
A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum β-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

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