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Silver-catalyzed exo-dig-azacyclization/[3+2] cycloaddition cascades on 1-tosylhydrazon-4-oxy-5-yne Substrates: Applicability to Diverse Alkenes
Journal article   Peer reviewed

Silver-catalyzed exo-dig-azacyclization/[3+2] cycloaddition cascades on 1-tosylhydrazon-4-oxy-5-yne Substrates: Applicability to Diverse Alkenes

Deepak B. Huple, Chun-Hao Chen, Arindam Das and Rai-Shung Liu
Advanced Synthesis and Catalysis, Vol.353(11-12), pp.1877-1882
08/2011
DOI: https://doi.org/10.1002/adsc.201100263

Abstract

6-exo-dig-azacyclization [3+2] cycloaddition azacyclic synthesis cascade reactions silver catalysis
We report the silver-catalyzed tandem 6-exo-dig-azacyclization/[3+2] cycloaddition cascade on 1-tosylhydrazon-4-oxy-5-ynes to form complicated azacyclic products regioselectively and efficiently. The new azacyclic syntheses have a wide range of reaction scope, with respect to both substrates and alkenes. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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