Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Cherng-Jyh Ke; Tzu-Yuan Su; Hsin-Lung Chen; Hao-Li Liu; Wei-Lun Chiang; Po-Chun Chu; Younan Xia; Hsing-Wen Sung

doi:10.1002/anie.201102852

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Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Journal article

Peer reviewed

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Cherng-Jyh Ke, Tzu-Yuan Su, Hsin-Lung Chen, Hao-Li Liu, Wei-Lun Chiang, Po-Chun Chu, Younan Xia and Hsing-Wen Sung

Angewandte Chemie - International Edition, Vol.50(35), pp.8086-8089

22/08/2011

DOI: https://doi.org/10.1002/anie.201102852

Abstract

controlled release

double emulsions

drug delivery

fluorescence

multifunctional particles

Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO ₃ entered the endocytic organelles of a live cell, the NaHCO ₃ in the aqueous core reacted with protons that infiltrated from the compartment to generate CO ₂ gas. The evolution of CO ₂ bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Title: Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments
Creators - without role: Cherng-Jyh Ke - Department of Chemical Engineering , National Tsing Hua University
Tzu-Yuan Su - Department of Chemical Engineering , National Tsing Hua University
Hsin-Lung Chen - Department of Chemical Engineering , National Tsing Hua University
Hao-Li Liu - Chang Gung University
Wei-Lun Chiang - Department of Chemical Engineering , National Tsing Hua University
Po-Chun Chu - Chang Gung University
Younan Xia - National Tsing Hua University
Hsing-Wen Sung - Department of Chemical Engineering , National Tsing Hua University
Publication Details: Angewandte Chemie - International Edition, Vol.50(35), pp.8086-8089
Identifiers: 9957771616606774
Academic Unit: Department of Chemical Engineering, College of Engineering, National Tsing Hua University; Institute of Biomedical Engineering, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Journal article

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

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