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Solvent-dependent chemoselectivity in ruthenium-catalyzed cyclization of iodoalkyne-epoxide functionalities
Journal article   Peer reviewed

Solvent-dependent chemoselectivity in ruthenium-catalyzed cyclization of iodoalkyne-epoxide functionalities

Ming-Yuan Lin, Shambabu Joseph Maddirala and Rai-Shung Liu
Organic Letters, Vol.7(9), pp.1745-1748
28/04/2005

Abstract

(Chemical Equation Presented) Treatment of 1-(2′-iodoethynylphenyl)- 2-propyloxirane (3) with TpRuPPh 3 (CH 3 CN) 2 PF 6 catalyst (10 mol %) produced 1-iodo-2-naphthol (3a) exclusively in DMF, but gave 2-iodobenzo[d]oxepin (3b) efficiently in benzene. Such a solvent-dependent chemoselectivity suggests a solution equilibrium between ruthenium-π-iodoalkyne and ruthenium-2-iodovinylidene intermediates. © 2005 American Chemical Society.

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