摘要
The reconstruction of bone defects remains challenging. The utilization of bone autografts, although quite promising, is limited by several drawbacks, especially substantial donor site complications. Recently, strontium (Sr), a bioactive trace element with excellent osteoinductive, osteocon-ductive, and pro-angiogenic properties, has emerged as a potential therapeutic agent for bone re-pair. Herein, a strontium peroxide (SrO 2 )-loaded poly(lactic-co-glycolic acid) (PLGA)-gelatin scaffold system was developed as an implantable bone substitute. Gelatin sponges serve as porous os-teoconductive scaffolds, while PLGA not only reinforces the mechanical strength of the gelatin but also controls the rate of water infiltration. The encapsulated SrO 2 can release Sr 2+ in a sustained manner upon exposure to water, thus effectively stimulating the proliferation of osteoblasts and suppressing the formation of osteoclasts. Moreover, SrO 2 can generate hydrogen peroxide and sub-sequent oxygen molecules to increase local oxygen tension, an essential niche factor for osteogene-sis. Collectively, the developed SrO 2 -loaded composite scaffold shows promise as a multifunctional bioactive bone graft for bone tissue engineering.