摘要
A fucose-containing glycoprotein fraction which stimulates spleen cell proliferation and cytokine expression has been dentified from the water-soluble extract of Ganoderma lucidum. Proteomic analysis of mouse spleen cells treated with this glycoprotein fraction showed ∼ 50% change of the proteome. Further studies on the activities of this glycoprotein fraction through selective proteolysis and glycosidic cleavage indicate that a fucose containing polysaccharide fraction is responsible for stimulating the expression of cytokines, especially IL- , IL-2 and INF-γ. Copyright © 2002 Elsevier Science Ltd.