Abstract
The syntheses of 5-fluoro (FaraU) and (E)-5-(2-fluorovinyl) arabinosyl uridine (FVAU) via 5-trimethylstannyl and (E)-5-(2-tributylstannylvinyl) arabinosyl uridine analogues with select-fluor is described. Boc protection of the uridine moiety improved the yield of synthesis and differences between N-Boc and O-Boc isomers were established by 1 H- and 13 C NMR. The Boc-protected stannyl intermediates may be fluorinated with 18 F to produce [ 18 F]FaraU and [ 18 F]FVAU. © Georg Thieme Verlag Stuttgart.