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Synthesis, Characterization, and Crystal Structure of a Chiral Platinum(II) Complex with 2-(4-Methoxy-Phenyl)-Imidazo[4, 5-f][l,10]-Phenanthroline Binding Interaction with DNA
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Synthesis, Characterization, and Crystal Structure of a Chiral Platinum(II) Complex with 2-(4-Methoxy-Phenyl)-Imidazo[4, 5-f][l,10]-Phenanthroline Binding Interaction with DNA

X.J. Luo, S.L. Wang, J.M. Xu, Y. Yang, Z.H. Luo, R.J. Liu 和 W.J. Liang
Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya, 卷.43(10), 頁碼.679-684
10/2017
DOI: https://doi.org/10.1134/S1070328417100050

摘要

DNA-binding fluorescent platinum complex Chemistry (all) Chemical Engineering (all)
A new platinum(II) complex of [Pt(Chda)(4-MOPIP)] 2+ 2Cl – · H 2 O (I) (Chda = cyclohexanediamine; 4-MOPIP = (4-methoxy-phenyl)-imidazo[4,5-f][l,10]-phenanthroline) has been synthesized by hydrothermal methods and characterized by elemental analysis, IR, single-crystal X-ray diffraction (CIF file CCDC no. 1472980), UV-Vis and fluorescent spectrum. In complex I, the platinum adopts a four-coordinated square planar geometry. The DNA-binding interaction has been investigated. The complex can bind to DNA by intercalative mode, presenting the high DNA-binding affinity.

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