摘要
A series of keto-amine bidentate precursors 1–5, OCCH 3 CHCCH 3 NHR (where 1, R = C 6 H 3 -2,6- i Pr 2 ; 2, R = C 6 H 2 -2,4,6-Me 3 ; 3, R = C 6 H 4 -2- t Bu; 4, R = C 6 H 4 -2-OMe; 5, R = C 6 H 4 -2-OMe-5-Me) were synthesized and combined with [Ru(ɳ 6 -p-cymene)Cl 2 ] 2 to generate the monomeric arene-Ru derivatives, [Ru(ɳ 6 -p-cymene)(OCCH 3 CHCCH 3 NR)Cl] (where 6, R = C 6 H 3 -2,6- i Pr 2 ; 7, R = C 6 H 2 -2,4,6-Me 3 ; 8, R = C 6 H 4 -2- t Bu; 9, R = C 6 H 4 -2-OMe; 10, R = C 6 H 4 -2-OMe-5-Me) in moderate yield. The ruthenium derivatives effectively catalyzed the conversion rate in transfer hydrogenation of substituted acetophenone. The molecular structures of 2, 6–10 were determined by single crystal X-ray diffractometry in the solid state, revealing a four-coordination environment around the Ru atom. The potential anti-cancer activity of ruthenium derivatives against human hormone-refractory metastatic prostate cancer (HRMPC) cell lines was also studied.