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Synthesis and immunofluorescence assay of a new biotinylated paclitaxel
Journal article   Peer reviewed

Synthesis and immunofluorescence assay of a new biotinylated paclitaxel

Thota Sambaiah, Ke-Yung King, Shwu-Chen Tsay, Nai-Wen Mei, Sharcon Hakimclahi, Yiu-Kay Lai, Chien-Hui Lieu and Jih Ru Hwu
European Journal of Medicinal Chemistry, Vol.37(4), pp.349-353
05/04/2002

Abstract

Biotin G2M-phase cell Immunofluorescence Paclitaxel Photo-affinity
7-(5′-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G 2 M phase only. © 2002 Published by Éditions scientifiques et médicales Elsevier SAS.

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