Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene

Kun-I. Lin; Li-Wu Chiang; Chien-Hung Wu; Shao-Wei Chen; Chung-Shan Yu

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Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene

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Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene

Kun-I. Lin, Li-Wu Chiang, Chien-Hung Wu, Shao-Wei Chen and Chung-Shan Yu

Journal of the Chinese Chemical Society, Vol.54(2), pp.563-568

2007

Abstract

Arabinosyl uridine

Cancer

HSV-1 TK

Radioiodine

Stannane

Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5-[ ¹²⁵ I]iodoarabinosyl uridine starting from commercially available uridine is reported herein.

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Title: Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene
Creators - without role: Kun-I. Lin - Department of Nuclear Science , National Tsing-Hua University
Li-Wu Chiang - Department of Nuclear Science , National Tsing-Hua University
Chien-Hung Wu - National Tsing Hua University
Shao-Wei Chen - Department of Nuclear Science , National Tsing-Hua University
Chung-Shan Yu - Department of Nuclear Science , National Tsing-Hua University
Identifiers: 9957777393706774
Academic Unit: Institute of Nuclear Engineering and Science, College of Nuclear Science, National Tsing Hua University
Language: English
Resource Type: Journal article
Publication Details: Journal of the Chinese Chemical Society, Vol.54(2), pp.563-568

Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene

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