摘要
The same biological activity as the antigen determinant sialyl Lewisx was shown by the fucopeptide 1 in a binding assay with E-selectin. In the design of this mimetic the type and spatial arrangement of the functional groups essential for the interaction between sialyl Lewisx and E-selectin were considered. Fucopeptide 1, which may have potential as an antiinflammatory agent, was synthesized from L-fucose. L-threonine, (2S,3R)-2-amino-3,4-dihydroxy-butyric acid, and glutarate.