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Synthesis of P38 map kinase inhibitor analogues compounds and quinoxalinone derivatives
Journal article   Peer reviewed

Synthesis of P38 map kinase inhibitor analogues compounds and quinoxalinone derivatives

Kuo Chu Hwang and Periyasamy Murugan
International Journal of Pharma and Bio Sciences, Vol.5(4), pp.P212-P224
2014

Abstract

1,3,5-trione Benzothiazine Inflammatory O-phenylenediamine p38 MAP kinase inhibitor Quinoxalinone Triarylimidazole Unsymmetrical diketones
This paper reports the synthesis of nitrogen containing heterocyclic compounds such as quinoxalines (5-7), imidazoles (8, 9,10,11), aminothiazole (12), aminooxazole (13), aminoimidazole (14) and benzothiazine (17) from the reaction with unsymmetrical diketone 4, 3 and 4a respectively. The aforementioned compounds with 4-pyridyl,4-fluorophenyl groups have different positions in their ring skeleton. The quinoxalinone derivatives (19, 20) were synthesized by the reaction of (18) with o-phenylenediamine and 4,5-dimethyl- o-phenylenediamine respectively.

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