摘要
We developed a low-energy visible-light-mediated synthesis of 2,5-dihydroxyaryl/alkyl ketones and 2,5-dihydroxybenzaldehyde using inexpensive and readily available starting materials, benzoquinones and alcohols, at room temperature. Herein, triplet excited state benzoquinone and singlet oxygen (1O2) play an essential role in the hydroacylation of benzoquinone. The current photochemical method is simple, green, and economically feasible, and works for both aryl methanol and aliphatic alcohols. Moreover, acyl hydroquinones are important precursors for the synthesis of various pharmaceutical drugs, including cynandione A and anti-cancer drugs. Meanwhile, 2,5-dihydroxybenzaldehyde is an essential precursor for the synthesis of gentisic acid.