Synthesis of phytosphingosine using olefin cross-metathesis: a convenient access to chain-modified phytosphingosines from d-lyxose

Chi-We Chang; Yeng-Nan Chen; Avijit Kumar Adak; Kun-Hsien Lin; Der-Lii M. Tzou; Chun-Cheng Lin

doi:10.1016/j.tet.2007.03.047

Synthesis of phytosphingosine using olefin cross-metathesis: a convenient access to chain-modified phytosphingosines from d-lyxose

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Synthesis of phytosphingosine using olefin cross-metathesis: a convenient access to chain-modified phytosphingosines from d-lyxose

Chi-We Chang, Yeng-Nan Chen, Avijit Kumar Adak, Kun-Hsien Lin, Der-Lii M. Tzou 和 Chun-Cheng Lin

Tetrahedron, 卷.63(20), 頁碼.4310-4318

05/2007

DOI: https://doi.org/10.1016/j.tet.2007.03.047

摘要

Cross-metathesis

Lipid

Phytosphingosine

Wittig reaction

Biochemistry

Organic Chemistry

Drug Discovery

This work establishes a general protocol for synthesizing phytosphingosines with various lengths of lipid chains. The synthetic strategy included the Wittig reaction and olefin cross-metathesis as key steps. Combining these two C-C bond formation methods provide rapid access to adequately protected phytosphingosine backbones. © 2007 Elsevier Ltd. All rights reserved.

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題名: Synthesis of phytosphingosine using olefin cross-metathesis: a convenient access to chain-modified phytosphingosines from d-lyxose
創作者：: Chi-We Chang (作者) - Institute of Chemistry, Academia Sinica
Yeng-Nan Chen (作者) - Department of Chemistry , National Tsing Hua University
Avijit Kumar Adak (作者) - National Tsing Hua University
Kun-Hsien Lin (作者) - Institute of Chemistry, Academia Sinica
Der-Lii M. Tzou (作者) - Institute of Chemistry, Academia Sinica
Chun-Cheng Lin (作者) - Department of Chemistry , National Tsing Hua University
學術資源類型: 期刊文章
出版日期: 05/2007
出版資訊: Tetrahedron, 卷.63(20), 頁碼.4310-4318
語言: 英語

Synthesis of phytosphingosine using olefin cross-metathesis: a convenient access to chain-modified phytosphingosines from d-lyxose

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