A practical synthetic method for the title disaccharide 2 is described. Glycosylation using thioglycoside as acceptor and glycosyl imidate as donor was performed with trimethylsilyltriflate as the promoter.
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Title
Synthesis of β-D-glucopyranosyl(1→3)-1-thiol-β-glucosamine disaccharide derivative as building block for the synthesis of hyaluronic acid
Creators - without role
Chun-Cheng Lin - Institute of Chemistry, Academia Sinica
Tzu-Sui Hsu - Institute of Chemistry, Academia Sinica
Kuo-Cheng Lu - Institute of Chemistry, Academia Sinica
I.-Ting Huang - Institute of Chemistry, Academia Sinica
Publication Details
Journal of the Chinese Chemical Society, Vol.47(4 B), pp.921-928