摘要
One of the two possible regioisomers can be exclusively formed by combining a suitable solvent and a specific amount of triethylamine as a base during the amination of allyl bromide 5. The S N 2′ product 7 was produced using dichloromethane as a solvent and triethylamine (7 equiv) as base; S N 2 product 6 was predominantly generated in hexane with 0.5 equivalents of triethylamine. Furthermore, a new reaction condition for the efficient cyclization of 7 to yield α-methylene β-lactam 8 using Sn[N(TMS) 2 ] 2 as a reagent, is disclosed. © Georg Thieme Verlag Stuttgart.