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The novel preparation of 99mTc(I)-labeled human serum albumin (HSA) nanoparticles as a SPECT imaging agent
Journal article   Peer reviewed

The novel preparation of 99mTc(I)-labeled human serum albumin (HSA) nanoparticles as a SPECT imaging agent

Wan-Jou Chen, Feng-Yun J. Huang, Hsiu-Yu Chang, Te-Wei Lee, Chien-Wen Chang and Jem-Mau Lo
Journal of Radioanalytical and Nuclear Chemistry, Vol.307(1), pp.141-150
01/2016
DOI: https://doi.org/10.1007/s10967-015-4094-5
Appears in  keyword about Chemistry

Abstract

99mTc(I)-tricarbonyl ion Human serum albumin (HSA) Nanoparticles (NPs) Tumor imaging [99mTc(OH2)3(CO)3]+ Analytical Chemistry,Nuclear Energy and Engineering,Health Toxicology and Mutagenesis,Pollution,Public Health Environmental and Occupational Health,Spectroscopy,Radiology Nuclear Medicine and Imaging
The purpose of this study was to develop a convenient and robust method for preparation of 99m Tc(I)-labeled human serum albumin nanoparticles (HSA-NPs) as a SPECT agent for tumor imaging. Efficient radiolabeling 99m Tc to HSA-NPs was achieved by simply reacting [ 99m Tc(OH 2 ) 3 (CO) 3 ] + with the reconstituted HSA-NPs solution. The size and morphology of 99m Tc(I)-HSA-NPs were analyzed and found not to significantly change after the preformed HSA-NPs were lyophilized or labeled with 99m Tc(I). By incubating 99m Tc(I)-HSA-NPs in rat plasma at 37 °C for 30 h, 75 % of the radioactivity were found to be remained in the particles, suggesting good in vitro stability.

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