Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer

Tzu-Chen Yen; Koon-Kwan Ng; Shih-Ya Ma; Hung-Hsueh Chou; Chien-Sheng Tsai; Swei Hsueh; Ting-Chang Chang; Ji-Hong Hong; Lai-Chu See; Wuu-Jyh Lin; Jenn-Tzong Chen; Kuan-Gen Huang; Kar-Wai Lui; Chyong-Huey Lai

doi:10.1200/JCO.2003.01.102

期刊文章

Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer

Tzu-Chen Yen, Koon-Kwan Ng, Shih-Ya Ma, Hung-Hsueh Chou, Chien-Sheng Tsai, Swei Hsueh, Ting-Chang Chang, Ji-Hong Hong, Lai-Chu See, Wuu-Jyh Lin, …

Journal of Clinical Oncology, 卷.21(19), 頁碼.3651-3658

10/2003

DOI: https://doi.org/10.1200/JCO.2003.01.102

PMID: 14512397

摘要

Oncology

Cancer Research

Purpose: The role of positron emission tomography (PET) with fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) in cervical cancer has not yet been well defined. We conducted a prospective study to investigate its efficacy in comparison with magnetic resonance imaging and/or computed tomography (MRI-CT). Materials and Methods: Patients with untreated locally advanced (35%) or recurrent (65%) cervical cancer were enrolled onto this study. In the first part of this study, 41 patients had a conventional FDG-PET (40 minutes after injection), and in the second part, 94 patients received dual-phase PET (at both 40 minutes and 3 hours after injection). The overall results of PET scans were compared with MRI-CT, and the two protocols of PET were also compared with each other. Lesion status was determined by pathology results or clinical follow-up. The receiver operating characteristic curve method with area under the curve (AUC) calculation was used to evaluate the discriminative power. Results: Overall (N = 135), FDG-PET was significantly superior to MRI-CT in identifying metastatic lesions (AUC, 0.971 v 0.879; P = .039), although the diagnostic accuracy was similar for local tumors. Dual-phase PET was also significantly better than the 40-minute PET (n = 94). The latter accurately recognized 70% of metastatic lesions and the former detected 90% (AUC, 0.943 v 0.951; P = .007). Dual-phase FDG-PET changed treatment of 29 patients (31%; upstaging 27% and downstaging 4%). Conclusion: This study shows that dual-phase FDG-PET is superior to conventional FDG-PET or MRI-CT in the evaluation of metastatic lesions in locally advanced or recurrent cervical cancer. © 2003 by American Society of Clinical Oncology.

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題名: Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer
翻譯題名: Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer
創作者：: Tzu-Chen Yen (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Koon-Kwan Ng (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Shih-Ya Ma (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Hung-Hsueh Chou (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Chien-Sheng Tsai (作者) - Chang Gung University
Swei Hsueh (作者) - Chang Gung University
Ting-Chang Chang (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Ji-Hong Hong (作者) - Chang Gung Memorial Hospital
Lai-Chu See (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Wuu-Jyh Lin (作者) - Linkou Chang Gung Memorial Hospital
Jenn-Tzong Chen (作者) - Chang Gung University
Kuan-Gen Huang (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Kar-Wai Lui (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
Chyong-Huey Lai (作者) - Department of Nuclear Medicine; Department of Radiology; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology; Department of Radiation Oncology; and Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University; Biostatistics Consulting Center/Department of Public Health, Chang Gung University; and Institute of Nuclear Energy Research, Taoyuan, Taiwan
學術資源類型: 期刊文章
出版日期: 10/2003
出版資訊: Journal of Clinical Oncology, 卷.21(19), 頁碼.3651-3658
語言: 英語

Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer

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