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Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction
期刊文章

Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction

Chang-Ching Lin, Yi-Shin Pan, Laxmikant N. Patkar, Hsiu-Mei Lin, Der-Lii M. Tzou, Thangaiah Subramanian 和 Chun-Cheng Lin
Bioorganic and Medicinal Chemistry, 卷.12(12), 頁碼.3259-3267
06/2004
DOI: https://doi.org/10.1016/j.bmc.2004.03.064
PMID: 15158794

摘要

Dihydroxylation Glycosidase inhibitor Iminocyclitols Ring-closing metathesis Biochemistry Molecular Medicine Molecular Biology Pharmaceutical Science Drug Discovery Clinical Biochemistry Organic Chemistry
Seven-membered iminocyclitols with diverse diastereomers were prepared starting with D- and L-serines and employing ring-closing olefin metathesis and dihydroxylation reaction sequence. The iminocyclitols were assayed for glycosidase inhibition and compound 20 was found to be a competitive inhibitor for β-glucosidase with K i 26.3μM. © 2004 Elsevier Ltd. All rights reserved.

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