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X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues
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X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues

C.-C. Chien, C.-C. Cheng, H.H. Chen, Y. Hwu, Y.S. Chu, C. Petibois, A. Chen, Y.-T. Ching 和 G. Margaritondo
Analytical and Bioanalytical Chemistry, 卷.404(5), 頁碼.1287-1296
09/2012
DOI: https://doi.org/10.1007/s00216-012-6217-y
PMID: 22918568

摘要

3D tissue imaging High resolution X-ray microscopy Nanoparticles Analytical Chemistry Biochemistry
We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs. © 2012 Springer-Verlag.

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