pH dependent thermal stabilization of DNA by Glcβ(1→3) GlcNAcβ1-→STol

Chun-Cheng Lin; Sue-Mei Hung; Kuo-Cheng Lu; Chien-Chung Cheng

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pH dependent thermal stabilization of DNA by Glcβ(1→3) GlcNAcβ1-→STol

Journal article

Peer reviewed

pH dependent thermal stabilization of DNA by Glcβ(1→3) GlcNAcβ1-→STol

Chun-Cheng Lin, Sue-Mei Hung, Kuo-Cheng Lu and Chien-Chung Cheng

Journal of the Chinese Chemical Society, Vol.51(3), pp.655-658

2004

Appears in keyword about Chemistry

Abstract

DNA-carbohydrate interaction

Hydrogen-bond

pH dependent

Thermal stabilization

Chemistry (all)

A disaccharide, Glcβ(1→3)GlcNAcβ1→STol (GGS, 1), was synthesized and demonstrated to stabilize ct-DNA during the denaturing process. GGS at 50 μM shifted T _m of ct-DNA by 23 °C and the behavior was pH dependent. Poly(dA-dT) ₂ was found to be the preferable type of DNA for GGS stabilization by circular dichroism spectroscopy study.

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Title: pH dependent thermal stabilization of DNA by Glcβ(1→3) GlcNAcβ1-→STol
Creators - without role: Chun-Cheng Lin - Institute of Chemistry, Academia Sinica
Sue-Mei Hung - Tamkang University
Kuo-Cheng Lu - Institute of Chemistry, Academia Sinica
Chien-Chung Cheng - Tamkang University
Publication Details: Journal of the Chinese Chemical Society, Vol.51(3), pp.655-658
Identifiers: 9957777199606774
Academic Unit: National Tsing Hua University
Language: English
Resource Type: Journal article

pH dependent thermal stabilization of DNA by Glcβ(1→3) GlcNAcβ1-→STol

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