Abstract
An implantable microdevice for investigating the efficiency of site-specific drug delivery, as well as real-time on-site evaluation of the endogenous or exogenous compounds as a result of the specific physiological stress/changes is described. The unique arrangement of the implantable microdevice makes it possible to carry out several diagnostic and therapeutic tasks concurrently, with or without additional functional coupling to other components or devices. Also described is a microdevice for in situ applying and/or monitoring a photodynamic therapy in a subject and methods of using the microdevice. A system for in situ delivering, detecting, and/or activating one or more samples in a subject is also described.