Abstract
The present invention related to derivatives of 5,8-quinolinedione exert anticancer and antimicrobial activities. A new synthetic compound 7-chloro-6-piperidin-1-yl-quinoline-5,8-dione, "PT-26-2' for short, whose chemical formula is C14H13C1N2O2. Pt-26-2 can stable the function of F-actin and cause the polymerization of F-actin, which induced the cell elongation in various cancer cells.Furthermore, PT-26-2 repressed the survival signals of Ras-ERK, and increased mitochondrial membrane potential, caspase-3 activation, and apoptosis in the A549 lung carcinoma cells because of its antitumor mechanism.In addition, the cell cycle-regulated proteins of cyclin B1 and phosphor-cdc2 were also repressed by PT-26-2, so as to stop the cycle of cancer cells and restrain the growth of them.