摘要
本發明提供一種口服醫藥組合物，其包含金屬錯合物以及外層。所述金屬錯合物係於由有機物配位鍵結至金屬離子而形成，其中所述有機物為芳香族化合物且包含至少二個氧原子。所述外層包含β-葡聚醣，β-葡聚醣分散於金屬錯合物外且配位鍵結至金屬錯合物構成所述外層。藉此，前述口服醫藥組合物可在極端的腸道環境中保持穩定，且能標靶微皺摺細胞經淋巴系統吸收進入體內，並被免疫細胞吞噬後攜帶至病灶處。
The invention relates to an oral pharmaceutical composition including a metal complex and an outer layer. The metal complex is formed by coordinate bonding of an organic to metal ions, wherein the organic is an aromatic compound and includes at least two oxygen atoms. The outer layer includes a β-glucan, and the β-glucan is dispersed outside the metal complex and is coordinately bonded to the metal complex to form the outer layer. Therefore, the oral pharmaceutical composition can be kept stable in the extreme intestinal environment, and can be absorbed into the body through the lymphatic system, and can be phagocytosed by immune cells and carried to the lesion.