Abstract
The present disclosure provides a temperature-responsive composition including a nitric oxide donor and a carrier. The nitric oxide donor is a pH-dependent material, and the carrier is provided for carrying the nitric oxide donor with an effective amount. The carrier includes a protective agent and an organic protic acid. A transition temperature of the temperature-responsive composition is larger than or equal to 28℃ and less than or equal to 37℃. Thereby, the present disclosure can prevent the nitric oxide from directly contacting with plasma of the human body for prolonging the half-life of the nitric oxide. Accordingly, the frequency of injecting the nitric oxide can be reduced.