Seven terpenoids were isolated from Artemisia argyi leaves, including one new triterpenoid featuring a unique terminal diagonal methoxy-substituted side chain and six known analogues. Their structures were confirmed by NMR and HR-ESI-MS spectral analyses, and the absolute stereochemistry of Compound 1 was elucidated via x-ray diffraction analysis. Bioassays revealed that 2 exhibited cytotoxicity against U251 glioma cells (IC50 = 5.6 & micro;M) and potently abrogated cell migration and invasion in a dose-proportional manner by suppressing PI3K/AKT/mTOR phosphorylation, as confirmed by Transwell and Western blot analyses. Bioinformatics analysis further suggested EGFR as a potential upstream target mediating these effects. These findings indicated A. argyi as a possible source of bioactive terpenoids with anti-glioma potential, providing a theoretical basis for further pharmacological studies.
- Anti-Glioma Activity of Artejasminolide Isolated From Artemisia argyi Based on Bioactivity Evaluation and Network Pharmacology
- Leyi Fu - Guangdong Pharmaceutical UniversityZhiling Yao - Guangdong Pharmaceutical UniversityJiming Chen - Guangdong Pharmaceutical UniversityZitian Peng - Jinan UniversityLiju Zhang - Jinan UniversityZhe Ren - Jinan UniversityTao Liu - First Affiliated Hospital of Jinan UniversityYifei Wang - Jinan UniversityZai-Fu Yao - 竹師教育學院
- Wiley
- 12
- 82373917; 82473972 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 202206010008 / Guangzhou Key Research and Development Program Guangzhou Municipal Science and Technology Bureau
- Journal article
- 01/02/2026
- Chemistry & biodiversity, Vol.23(2), p.e03722
- English